Assay Detail
Binding
CHEMBL803424
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Inhibitory activity against purified recombinant human renin
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Piperidine-renin inhibitors compounds with improved physicochemical properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 8.30 | 10.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL430539 | — | — | 1 | 10.06 |
| CHEMBL286413 | — | — | 1 | 9.40 |
| CHEMBL285146 | — | — | 1 | 9.30 |
| CHEMBL32002 | — | — | 1 | 9.17 |
| CHEMBL31881 | — | — | 1 | 9.04 |
| CHEMBL287023 | — | — | 1 | 8.74 |
| CHEMBL31880 | — | — | 1 | 8.64 |
| CHEMBL31675 | — | — | 1 | 8.48 |
| CHEMBL30618 | — | — | 1 | 8.40 |
| CHEMBL31466 | — | — | 1 | 8.30 |
| CHEMBL283046 | — | — | 1 | 8.29 |
| CHEMBL281299 | — | — | 1 | 8.19 |
| CHEMBL285046 | — | — | 1 | 8.10 |
| CHEMBL31428 | — | — | 1 | 8.05 |
| CHEMBL31404 | — | — | 1 | 8.00 |
| CHEMBL285779 | — | — | 1 | 7.92 |
| CHEMBL265984 | — | — | 1 | 7.92 |
| CHEMBL284690 | — | — | 1 | 7.66 |
| CHEMBL30846 | — | — | 1 | 6.23 |
| CHEMBL277738 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL430539 | — | IC50 | = | 0.087 | nM | 10.06 |
| CHEMBL286413 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL285146 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL32002 | — | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL31881 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL287023 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL31880 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL31675 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL30618 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL31466 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL283046 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL281299 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL285046 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL31428 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL31404 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL285779 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL265984 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL284690 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL30846 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL277738 | — | IC50 | = | 820.0 | nM | 6.09 |