Assay Detail
Binding
CHEMBL803427
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Compound was tested for the inhibition of human plasma renin(Hu Renin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Preparation of a novel series of phosphonate norstatine renin inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.58 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59973 | — | — | 1 | 9.22 |
| CHEMBL60550 | TERLAKIREN | 2.0 | 1 | 9.15 |
| CHEMBL62054 | — | — | 1 | 8.24 |
| CHEMBL59984 | — | — | 1 | 7.60 |
| CHEMBL408572 | — | — | 1 | 7.50 |
| CHEMBL262672 | — | — | 1 | 7.22 |
| CHEMBL292726 | — | — | 1 | 6.72 |
| CHEMBL304446 | — | — | 1 | 6.72 |
| CHEMBL292502 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59973 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL60550 | TERLAKIREN | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL62054 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL59984 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL408572 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL262672 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL292726 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL304446 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL292502 | — | IC50 | = | 1400.0 | nM | 5.85 |