Assay Detail
Functional
CHEMBL803437
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Dose required to inhibit HIV-1 recombinant reverse transcriptase (rRT) activity by 50%.
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and anti-HIV-1 activity of thio analogues of dihydroalkoxybenzyloxopyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.49 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112886 | — | — | 1 | 5.92 |
| CHEMBL284241 | — | — | 1 | 5.89 |
| CHEMBL322539 | — | — | 1 | 5.66 |
| CHEMBL109389 | — | — | 1 | 5.62 |
| CHEMBL110857 | — | — | 1 | 5.60 |
| CHEMBL110007 | — | — | 1 | 5.60 |
| CHEMBL109551 | — | — | 1 | 5.60 |
| CHEMBL110008 | — | — | 1 | 5.58 |
| CHEMBL110009 | — | — | 1 | 5.58 |
| CHEMBL111153 | — | — | 1 | 5.57 |
| CHEMBL32469 | — | — | 1 | 5.57 |
| CHEMBL114404 | — | — | 1 | 5.55 |
| CHEMBL111368 | — | — | 1 | 5.54 |
| CHEMBL114292 | — | — | 1 | 5.52 |
| CHEMBL33238 | — | — | 1 | 5.47 |
| CHEMBL112949 | — | — | 1 | 5.47 |
| CHEMBL109637 | — | — | 1 | 5.37 |
| CHEMBL108944 | — | — | 1 | 5.37 |
| CHEMBL320735 | — | — | 1 | 5.37 |
| CHEMBL111118 | — | — | 1 | 5.34 |
| CHEMBL111088 | — | — | 1 | 5.34 |
| CHEMBL109721 | — | — | 1 | 5.31 |
| CHEMBL111523 | — | — | 1 | 5.21 |
| CHEMBL419025 | — | — | 1 | 5.08 |
| CHEMBL109213 | — | — | 1 | 5.03 |
| CHEMBL107607 | — | — | 1 | - |
| CHEMBL111152 | — | — | 1 | - |
| CHEMBL419928 | — | — | 1 | - |
| CHEMBL111449 | — | — | 1 | - |
| CHEMBL111181 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112886 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL284241 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL322539 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL109389 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL110857 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL110007 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL109551 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL110008 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL110009 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL111153 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL32469 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL114404 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL111368 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL114292 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL112949 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL33238 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL109637 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL320735 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL108944 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL111118 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL111088 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL109721 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL111523 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL419025 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL109213 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL107607 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL111152 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL419928 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL111449 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL111181 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL109807 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL109772 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL109512 | — | IC50 | > | 10000.0 | nM | - |