Assay Detail
Binding
CHEMBL803572
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Displacement of [3H]rolipram from rat brain membranes
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Novel heterocyclic-fused pyridazinones as potent and selective phosphodiesterase IV inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.32 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414613 | — | — | 1 | 8.32 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 8.22 |
| CHEMBL283179 | — | — | 1 | 6.40 |
| CHEMBL33501 | — | — | 1 | 6.00 |
| CHEMBL31725 | — | — | 1 | 6.00 |
| CHEMBL30894 | — | — | 1 | 5.80 |
| CHEMBL29546 | — | — | 1 | 5.75 |
| CHEMBL285457 | — | — | 1 | 5.70 |
| CHEMBL30593 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414613 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL283179 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL33501 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL31725 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL30894 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL29546 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL285457 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL30593 | — | IC50 | = | 22000.0 | nM | 4.66 |