Assay Detail
Functional
CHEMBL803575
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Displacement of [3H]rolipram from high affinity binding site (HARBS) in rat brain membrane.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 2,5-dihydropyrazol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.74 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 8.22 |
| CHEMBL88990 | NITRAQUAZONE | 2.0 | 1 | 8.00 |
| CHEMBL327581 | — | — | 1 | 6.05 |
| CHEMBL88527 | — | — | 1 | 6.00 |
| CHEMBL90189 | — | — | 1 | 5.92 |
| CHEMBL314537 | — | — | 1 | 5.82 |
| CHEMBL91952 | — | — | 1 | 5.70 |
| CHEMBL316449 | — | — | 1 | 5.70 |
| CHEMBL90335 | — | — | 1 | 5.33 |
| CHEMBL91007 | — | — | 1 | 5.30 |
| CHEMBL88442 | — | — | 1 | 5.25 |
| CHEMBL314088 | — | — | 1 | 5.22 |
| CHEMBL90920 | — | — | 1 | 4.85 |
| CHEMBL314089 | — | — | 1 | 4.46 |
| CHEMBL92004 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63 | ROLIPRAM | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL88990 | NITRAQUAZONE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL327581 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL88527 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL90189 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL314537 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL91952 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL316449 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL90335 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL91007 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL88442 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL314088 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL90920 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL314089 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL92004 | — | IC50 | = | 50000.0 | nM | 4.30 |