Assay Detail
Binding
CHEMBL803637
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Inhibitory activity against HIV-1 Reverse transcriptase wild-type (RT wt)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Inhibition of human immunodeficiency virus reverse transcriptase by synadenol triphosphate and its E-isomer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.93 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL145297 | — | — | 1 | 6.50 |
| CHEMBL1383 | DDA-TRIPHOSPHATE | -1.0 | 1 | 6.29 |
| CHEMBL145474 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL145297 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL1383 | DDA-TRIPHOSPHATE | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL145474 | — | Ki | = | 10000.0 | nM | 5.00 |