Assay Detail
Binding
CHEMBL803828
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Tested for the binding affinity towards 5-HT2 receptor measured by [3H]ketanserin binding to frontal cerebral cortex membranes of rat
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Frontal cortex |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
5-HT2 antagonist activity of 3-aminomethyltetralones
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.73 | 8.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1065 | METHYSERGIDE | 4.0 | 1 | 8.84 |
| CHEMBL308480 | — | — | 1 | 8.80 |
| CHEMBL72649 | — | — | 1 | 7.29 |
| CHEMBL310734 | — | — | 1 | 7.25 |
| CHEMBL310153 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1065 | METHYSERGIDE | Ki | = | 1.445 | nM | 8.84 |
| CHEMBL308480 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL72649 | — | Ki | = | 51.29 | nM | 7.29 |
| CHEMBL310734 | — | Ki | = | 56.23 | nM | 7.25 |
| CHEMBL310153 | — | Ki | = | 331.13 | nM | 6.48 |