Assay Detail
Functional
CHEMBL803946
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Cytotoxicity was determined in vitro in SKVLB cells(ovarian with upregulated MDRp-glycoprotein) of human tumor cell lines by using MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-VLB |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.06 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338843 | — | — | 1 | 8.10 |
| CHEMBL128315 | — | — | 1 | 7.77 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.39 |
| CHEMBL341028 | — | — | 1 | 6.99 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 6.83 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338843 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL128315 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL341028 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 5650.0 | nM | 5.25 |