Assay Detail
Functional
CHEMBL803947
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration that reduced the viability of SKVLB cell population by 50%.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-VLB |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Camptothecin and minor-groove binder hybrid molecules: synthesis, inhibition of topoisomerase I, and anticancer cytotoxicity in vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.64 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.28 |
| CHEMBL72627 | — | — | 1 | 5.68 |
| CHEMBL72828 | — | — | 1 | 5.46 |
| CHEMBL73002 | — | — | 1 | 5.24 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.18 |
| CHEMBL74459 | — | — | 1 | 5.01 |
| CHEMBL70433 | — | — | 1 | - |
| CHEMBL74406 | — | — | 1 | - |
| CHEMBL11252 | STALLIMYCIN | 2.0 | 1 | - |
| CHEMBL312306 | — | — | 1 | - |
| CHEMBL386919 | — | — | 1 | - |
| CHEMBL307767 | NETROPSIN | — | 1 | - |
| CHEMBL311855 | — | — | 1 | - |
| CHEMBL265320 | — | — | 1 | - |
| CHEMBL312690 | — | — | 1 | - |
| CHEMBL72927 | — | — | 1 | - |
| CHEMBL64874 | — | — | 1 | - |
| CHEMBL72353 | — | — | 1 | - |
| CHEMBL266468 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL72627 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL72828 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL73002 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 6540.0 | nM | 5.18 |
| CHEMBL74459 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL70433 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL74406 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL11252 | STALLIMYCIN | IC50 | > | 10000.0 | nM | - |
| CHEMBL312306 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL386919 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL307767 | NETROPSIN | IC50 | > | 10000.0 | nM | - |
| CHEMBL311855 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL265320 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL312690 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL72927 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL64874 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL72353 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL266468 | — | IC50 | > | 10000.0 | nM | - |