Assay Detail
Functional
CHEMBL803948
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Inhibitory activity was evaluated against human SKW 6.4 cell line in cellular assay
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SKW 6.4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 5.86 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92848 | — | — | 1 | 6.96 |
| CHEMBL91406 | — | — | 1 | 6.82 |
| CHEMBL90185 | — | — | 1 | 6.64 |
| CHEMBL94069 | — | — | 1 | 6.57 |
| CHEMBL93960 | — | — | 1 | 6.47 |
| CHEMBL92317 | — | — | 1 | 6.42 |
| CHEMBL316289 | — | — | 1 | 6.39 |
| CHEMBL90293 | — | — | 1 | 6.39 |
| CHEMBL91442 | — | — | 1 | 6.32 |
| CHEMBL90516 | — | — | 1 | 6.30 |
| CHEMBL88358 | — | — | 1 | 6.24 |
| CHEMBL316450 | — | — | 1 | 6.21 |
| CHEMBL327683 | — | — | 1 | 6.14 |
| CHEMBL91032 | — | — | 1 | 6.12 |
| CHEMBL330534 | — | — | 1 | 6.07 |
| CHEMBL315954 | — | — | 1 | 6.04 |
| CHEMBL314733 | — | — | 1 | 6.04 |
| CHEMBL327207 | — | — | 1 | 6.03 |
| CHEMBL328988 | — | — | 1 | 5.98 |
| CHEMBL88786 | — | — | 1 | 5.97 |
| CHEMBL327211 | — | — | 1 | 5.92 |
| CHEMBL90589 | — | — | 1 | 5.92 |
| CHEMBL327821 | — | — | 1 | 5.90 |
| CHEMBL314096 | — | — | 1 | 5.81 |
| CHEMBL328066 | — | — | 1 | 5.81 |
| CHEMBL330110 | — | — | 1 | 5.80 |
| CHEMBL315868 | — | — | 1 | 5.79 |
| CHEMBL327464 | — | — | 1 | 5.75 |
| CHEMBL91279 | — | — | 1 | 5.75 |
| CHEMBL316102 | — | — | 1 | 5.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92848 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL91406 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL90185 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL94069 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL93960 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL92317 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL316289 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL90293 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL91442 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL90516 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL88358 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL316450 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL327683 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL91032 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL330534 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL315954 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL314733 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL327207 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL328988 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL88786 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL327211 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL90589 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL327821 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL328066 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL314096 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL330110 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL315868 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL327464 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL91279 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL316102 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL88719 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL93177 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL327458 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1160622 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL92029 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL313158 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL88467 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL92494 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL316101 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL91825 | — | IC50 | = | 14020.0 | nM | 4.85 |
| CHEMBL90648 | — | IC50 | = | 18330.0 | nM | 4.74 |
| CHEMBL1160621 | — | IC50 | = | 19090.0 | nM | 4.72 |
| CHEMBL1160598 | — | IC50 | = | 30100.0 | nM | 4.52 |
| CHEMBL88765 | — | IC50 | > | 100000.0 | nM | - |