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Assay Detail

CHEMBL804028

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro cellular toxicity against human ovarian carcinoma SKOV3 cell line after 4 hr of compound exposure
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SK-OV-3
Confidence 1 — Organism
Curated By Expert

Target

SK-OV-3 (CHEMBL614925)
Type CELL-LINE
Organism Homo sapiens

Publication

Unsymmetrical DNA cross-linking agents: combination of the CBI and PBD pharmacophores.
Tercel M, Stribbling SM, Sheppard H, Siim BG, Wu K, Pullen SM, Botting KJ, Wilson WR, Denny WA.
J Med Chem (2003) 46 : 2132 -2151
PubMed 12747786 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 7.55 10.49

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL302536 1 10.49
CHEMBL302363 1 9.85
CHEMBL66051 1 9.54
CHEMBL432909 1 8.72
CHEMBL307572 1 8.52
CHEMBL307801 1 8.21
CHEMBL70011 1 7.96
CHEMBL69680 1 7.80
CHEMBL69443 1 7.46
CHEMBL279754 DSB-120 1 6.85
CHEMBL307542 1 6.70
CHEMBL305208 1 6.44
CHEMBL70019 1 6.02
CHEMBL293096 1 5.72
CHEMBL302819 1 5.68
CHEMBL66736 1 4.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL302536 IC50 = 0.032 nM 10.49
CHEMBL302363 IC50 = 0.14 nM 9.85
CHEMBL66051 IC50 = 0.29 nM 9.54
CHEMBL432909 IC50 = 1.9 nM 8.72
CHEMBL307572 IC50 = 3.0 nM 8.52
CHEMBL307801 IC50 = 6.2 nM 8.21
CHEMBL70011 IC50 = 11.0 nM 7.96
CHEMBL69680 IC50 = 16.0 nM 7.80
CHEMBL69443 IC50 = 35.0 nM 7.46
CHEMBL279754 DSB-120 IC50 = 140.0 nM 6.85
CHEMBL307542 IC50 = 200.0 nM 6.70
CHEMBL305208 IC50 = 360.0 nM 6.44
CHEMBL70019 IC50 = 960.0 nM 6.02
CHEMBL293096 IC50 = 1900.0 nM 5.72
CHEMBL302819 IC50 = 2100.0 nM 5.68
CHEMBL66736 IC50 = 14000.0 nM 4.85