Assay Detail
Binding
CHEMBL804071
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Inhibition of HIV-1 RT using rC-dG as template
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
5-chloro-3-(phenylsulfonyl)indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.63 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283950 | L-737126 | — | 1 | 8.52 |
| CHEMBL286759 | — | — | 1 | 7.85 |
| CHEMBL23456 | — | — | 1 | 7.66 |
| CHEMBL23401 | — | — | 1 | 7.64 |
| CHEMBL268871 | L-697661 | — | 1 | 7.44 |
| CHEMBL280551 | — | — | 1 | 7.20 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 7.00 |
| CHEMBL285799 | — | — | 1 | 6.95 |
| CHEMBL24273 | — | — | 1 | 6.81 |
| CHEMBL293498 | — | — | 1 | 6.51 |
| CHEMBL286378 | — | — | 1 | 6.13 |
| CHEMBL280527 | ATEVIRDINE MESYLATE | 2.0 | 1 | 5.88 |
| CHEMBL286404 | — | — | 1 | 5.60 |
| CHEMBL24214 | — | — | 1 | 4.14 |
| CHEMBL23678 | — | — | 1 | 4.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283950 | L-737126 | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL286759 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL23456 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL23401 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL268871 | L-697661 | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL280551 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL285799 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL24273 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL293498 | — | IC50 | = | 311.0 | nM | 6.51 |
| CHEMBL286378 | — | IC50 | = | 746.0 | nM | 6.13 |
| CHEMBL280527 | ATEVIRDINE MESYLATE | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL286404 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL24214 | — | IC50 | = | 72800.0 | nM | 4.14 |
| CHEMBL23678 | — | IC50 | = | 87600.0 | nM | 4.06 |