Assay Detail
Binding
CHEMBL804072
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Inhibition single mutant of HIV-1 RT (K103 N)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
5-chloro-3-(phenylsulfonyl)indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.46 | 6.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283950 | L-737126 | — | 1 | 6.94 |
| CHEMBL268871 | L-697661 | — | 1 | 6.26 |
| CHEMBL280551 | — | — | 1 | 5.59 |
| CHEMBL23401 | — | — | 1 | 5.56 |
| CHEMBL293498 | — | — | 1 | 5.13 |
| CHEMBL280527 | ATEVIRDINE MESYLATE | 2.0 | 1 | 4.48 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283950 | L-737126 | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL268871 | L-697661 | IC50 | = | 545.0 | nM | 6.26 |
| CHEMBL280551 | — | IC50 | = | 2570.0 | nM | 5.59 |
| CHEMBL23401 | — | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL293498 | — | IC50 | = | 7320.0 | nM | 5.13 |
| CHEMBL280527 | ATEVIRDINE MESYLATE | IC50 | = | 33400.0 | nM | 4.48 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 57900.0 | nM | 4.24 |