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Assay Detail

CHEMBL804104

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Functional
Ability to reverse NPY-induced intracellular [Ca2+] mobilization in SK-N-MC cells
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SK-N-MC
Confidence 1 — Organism
Curated By Intermediate

Target

SK-N-MC (CHEMBL614163)
Type CELL-LINE
Organism Homo sapiens

Publication

Potent and selective 1,2,3-trisubstituted indole NPY Y-1 antagonists.
Hipskind PA, Lobb KL, Nixon JA, Britton TC, Bruns RF, Catlow J, Dieckman-McGinty DK, Gackenheimer SL, Gitter BD, Iyengar S, Schober DA, Simmons RM, Swanson S, Zarrinmayeh H, Zimmerman DM, Gehlert DR.
J Med Chem (1997) 40 : 3712 -3714
PubMed 9371234 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 8.49 8.49

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL329536 1 8.49

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL329536 Ki = 3.2 nM 8.49