Assay Detail
Functional
CHEMBL804109
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Ability to antagonize 1 nM NPY''s inhibition of forskolin-stimulated cyclic AMP accumulation in SK-N-MC cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-N-MC |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity relationship of a series of diaminoalkyl substituted benzimidazole as neuropeptide Y Y1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.56 | 9.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL155802 | — | — | 1 | 9.25 |
| CHEMBL346242 | — | — | 1 | 8.47 |
| CHEMBL156076 | — | — | 1 | 8.28 |
| CHEMBL349328 | — | — | 1 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL155802 | — | Ki | = | 0.564 | nM | 9.25 |
| CHEMBL346242 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL156076 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL349328 | — | Ki | = | 6.0 | nM | 8.22 |