Assay Detail
Functional
CHEMBL804110
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro functional activity determined by its ability to antagonize 1 nM NPYs inhibition of forskolin -stimulated cyclic AMP accumulation in SK-N-MC cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-N-MC |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of a series of novel 2-[(4-chlorophenoxy)methyl]benzimidazoles as selective neuropeptide Y Y1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.27 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61532 | — | — | 1 | 8.57 |
| CHEMBL44246 | — | — | 1 | 7.96 |
| CHEMBL91462 | — | — | 1 | 7.82 |
| CHEMBL93535 | — | — | 1 | 7.28 |
| CHEMBL90717 | — | — | 1 | 7.19 |
| CHEMBL328541 | — | — | 1 | 7.11 |
| CHEMBL330223 | — | — | 1 | 7.06 |
| CHEMBL93375 | — | — | 1 | 7.04 |
| CHEMBL328460 | — | — | 1 | 6.92 |
| CHEMBL328532 | — | — | 1 | 6.86 |
| CHEMBL92148 | — | — | 1 | 6.82 |
| CHEMBL94292 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61532 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL44246 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL91462 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL93535 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL90717 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL328541 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL330223 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL93375 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL328460 | — | Ki | = | 119.0 | nM | 6.92 |
| CHEMBL328532 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL92148 | — | Ki | = | 153.0 | nM | 6.82 |
| CHEMBL94292 | — | Ki | = | 240.0 | nM | 6.62 |