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Assay Detail

CHEMBL804111

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Functional
Inhibition of NPY induced intracellular Ca++ mobilization in SK-N-MC cells is evaluated.
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SK-N-MC
Confidence 1 — Organism
Curated By Intermediate

Target

SK-N-MC (CHEMBL614163)
Type CELL-LINE
Organism Homo sapiens

Publication

Structure-activity relationships of a series of 1-substituted-4-methylbenzimidazole neuropeptide Y-1 receptor antagonists.
Zimmerman DM, Cantrell BE, Smith EC, Nixon JA, Bruns RF, Gitter B, Hipskind PA, Ornstein PL, Zarrinmayeh H, Britton TC, Schober DA, Gehlert DR.
Bioorg Med Chem Lett (1998) 8 : 473 -476
PubMed 9871601 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 7.58 7.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL145714 1 7.58

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL145714 Ki = 26.0 nM 7.58