Assay Detail
Binding
CHEMBL804129
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Inhibitory activity against bovine liver S-adenosyl-L-homocysteine hydrolase (AdoHcy).
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
4'-modified analogues of aristeromycin and neplanocin A: synthesis and inhibitory activity toward S-adenosyl-L-homocysteine hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.40 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301499 | — | — | 1 | 7.92 |
| CHEMBL50728 | — | — | 1 | 7.66 |
| CHEMBL50306 | — | — | 1 | 7.57 |
| CHEMBL299961 | — | — | 1 | 7.31 |
| CHEMBL296392 | — | — | 1 | 6.23 |
| CHEMBL299999 | — | — | 1 | 5.30 |
| CHEMBL299135 | — | — | 1 | 5.04 |
| CHEMBL298188 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301499 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL50728 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL50306 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL299961 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL296392 | — | Ki | = | 586.0 | nM | 6.23 |
| CHEMBL299999 | — | Ki | = | 5020.0 | nM | 5.30 |
| CHEMBL299135 | — | Ki | = | 9150.0 | nM | 5.04 |
| CHEMBL298188 | — | Ki | = | 67600.0 | nM | 4.17 |