Assay Detail
Binding
CHEMBL804178
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cross Resistance (antiviral activity) with NL4-3(WT) NNRTI (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and biological activity of novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 2-Aryl-substituted benzimidazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.08 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135127 | — | — | 1 | 6.52 |
| CHEMBL293961 | — | — | 1 | 6.30 |
| CHEMBL53554 | THIAZOLOBENZIMIDAZOLE | — | 1 | 5.77 |
| CHEMBL58581 | — | — | 1 | 5.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135127 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL293961 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL53554 | THIAZOLOBENZIMIDAZOLE | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL58581 | — | EC50 | = | 1850.0 | nM | 5.73 |