Assay Detail
Binding
CHEMBL804181
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Effective concentration required against L100I mutant HIV-1 reverse transcriptase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Antiviral drug design: computational analyses of the effects of the L100I mutation for HIV-RT on the binding of NNRTIs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.86 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35033 | EMIVIRINE | 2.0 | 1 | 7.70 |
| CHEMBL54893 | UC 781 | 1.0 | 1 | 7.62 |
| CHEMBL293498 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35033 | EMIVIRINE | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL54893 | UC 781 | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL293498 | — | EC50 | = | 5600.0 | nM | 5.25 |