Assay Detail
Binding
CHEMBL804227
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HIV-1 reverse transcriptase inhibitory activity against Wild Type Reverse transcriptase using (poly)rC600*(oligo)dGT as template primer.
24
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Urea-PETT compounds as a new class of HIV-1 reverse transcriptase inhibitors. 3. Synthesis and further structure-activity relationship studies of PETT analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 8.08 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL131643 | — | — | 1 | 8.89 |
| CHEMBL541204 | — | — | 1 | 8.80 |
| CHEMBL134278 | — | — | 3 | 8.57 |
| CHEMBL133658 | — | — | 1 | 8.57 |
| CHEMBL287317 | — | — | 1 | 8.52 |
| CHEMBL133559 | — | — | 1 | 8.46 |
| CHEMBL134026 | — | — | 2 | 8.42 |
| CHEMBL36424 | — | — | 1 | 8.40 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.40 |
| CHEMBL340047 | — | — | 1 | 8.37 |
| CHEMBL131972 | — | — | 1 | 8.28 |
| CHEMBL135105 | — | — | 1 | 8.28 |
| CHEMBL132425 | — | — | 1 | 8.17 |
| CHEMBL593 | DELAVIRDINE | 4.0 | 1 | 8.10 |
| CHEMBL336426 | — | — | 1 | 7.80 |
| CHEMBL39665 | — | — | 1 | 7.60 |
| CHEMBL40562 | — | — | 1 | 6.96 |
| CHEMBL133779 | — | — | 1 | 6.87 |
| CHEMBL132122 | — | — | 1 | 6.77 |
| CHEMBL132259 | — | — | 1 | 6.65 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL131643 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL541204 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL134278 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL133658 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL287317 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL134278 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL133559 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL134026 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL36424 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL340047 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL134026 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL135105 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL131972 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL132425 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL593 | DELAVIRDINE | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL134278 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL336426 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL39665 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL40562 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL133779 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL132122 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL132259 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 1.3 | nM | - |