Assay Detail
Binding
CHEMBL804234
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for enzymatic inhibitory activity against recombinant HIV reverse transcriptase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
5-Alkyl-2-[(methylthiomethyl)thio]-6-(benzyl)-pyrimidin-4-(1H)-ones as potent non-nucleoside reverse transcriptase inhibitors of S-DABO series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.07 | 5.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35655 | — | — | 1 | 5.32 |
| CHEMBL35755 | — | — | 1 | 5.21 |
| CHEMBL36031 | — | — | 1 | 5.01 |
| CHEMBL32386 | — | — | 1 | 4.73 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35655 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL35755 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL36031 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL32386 | — | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL129 | ZIDOVUDINE | IC50 | > | 100000.0 | nM | - |