Assay Detail
Binding
CHEMBL804262
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In vitro antiviral activity against HIV-1 Reverse transcriptase M184V mutant
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
The role of 2',3'-unsaturation on the antiviral activity of anti-HIV nucleosides against 3TC-resistant mutant (M184V).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.99 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38700 | ELVUCITABINE | 2.0 | 1 | 6.85 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 6.30 |
| CHEMBL1380 | ABACAVIR | 4.0 | 1 | 4.81 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38700 | ELVUCITABINE | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL991 | STAVUDINE | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1380 | ABACAVIR | EC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL141 | LAMIVUDINE | EC50 | > | 50000.0 | nM | - |