Assay Detail
Binding
CHEMBL804265
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV-1 reverse transcriptase using a poly(rC):oligo(dG)12-18 template primer
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Structural analogues of the calanolide anti-HIV agents. Modification of the trans-10,11-dimethyldihydropyran-12-ol ring (ring C).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.28 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267447 | CALANOLIDE A | 1.0 | 2 | 6.50 |
| CHEMBL267693 | — | — | 1 | 5.70 |
| CHEMBL7840 | — | — | 1 | 5.50 |
| CHEMBL266552 | — | — | 1 | 5.30 |
| CHEMBL267679 | — | — | 1 | 4.50 |
| CHEMBL269090 | — | — | 1 | 4.40 |
| CHEMBL266091 | — | — | 1 | 4.30 |
| CHEMBL7378 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267447 | CALANOLIDE A | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL267447 | CALANOLIDE A | EC50 | = | 970.0 | nM | 6.01 |
| CHEMBL267693 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL7840 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL266552 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL267679 | — | EC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL269090 | — | EC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL266091 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL7378 | — | EC50 | > | 100000.0 | nM | - |