Assay Detail
Binding
CHEMBL804266
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Inhibition of reverse transcriptase of HIV-1 (strain RF)-infected MT-4 cells in RPMI 1640 growth medium in MTM assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and anti-HIV-1 activity of a series of imidazo[1,5-b]pyridazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 30 | 6.37 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.52 |
| CHEMBL268871 | L-697661 | — | 1 | 8.15 |
| CHEMBL434441 | — | — | 1 | 8.00 |
| CHEMBL338099 | — | — | 1 | 8.00 |
| CHEMBL125446 | — | — | 1 | 7.70 |
| CHEMBL127427 | — | — | 1 | 6.40 |
| CHEMBL125532 | — | — | 1 | 6.36 |
| CHEMBL340248 | — | — | 1 | 6.23 |
| CHEMBL1203237 | — | — | 1 | 6.20 |
| CHEMBL123202 | — | — | 1 | 6.16 |
| CHEMBL435017 | — | — | 1 | 6.14 |
| CHEMBL338339 | — | — | 1 | 6.11 |
| CHEMBL125084 | — | — | 1 | 6.07 |
| CHEMBL338823 | — | — | 1 | 6.05 |
| CHEMBL125205 | — | — | 1 | 6.00 |
| CHEMBL126216 | — | — | 1 | 5.96 |
| CHEMBL435216 | — | — | 1 | 5.89 |
| CHEMBL341512 | — | — | 1 | 5.75 |
| CHEMBL1203236 | — | — | 1 | 5.03 |
| CHEMBL126811 | — | — | 1 | 4.60 |
| CHEMBL332351 | — | — | 1 | 4.55 |
| CHEMBL338302 | — | — | 1 | - |
| CHEMBL338415 | — | — | 1 | - |
| CHEMBL124271 | — | — | 1 | - |
| CHEMBL341238 | — | — | 1 | - |
| CHEMBL123514 | — | — | 1 | - |
| CHEMBL121820 | — | — | 1 | - |
| CHEMBL124246 | — | — | 1 | - |
| CHEMBL124248 | — | — | 1 | - |
| CHEMBL123839 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL268871 | L-697661 | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL434441 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL338099 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL125446 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL127427 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL125532 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL340248 | — | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1203237 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL123202 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL435017 | — | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL338339 | — | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL125084 | — | EC50 | = | 860.0 | nM | 6.07 |
| CHEMBL338823 | — | EC50 | = | 890.0 | nM | 6.05 |
| CHEMBL125205 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL126216 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL435216 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL341512 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1203236 | — | EC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL126811 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL332351 | — | EC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL338302 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL338415 | — | EC50 | > | 260000.0 | nM | - |
| CHEMBL124271 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL341238 | — | EC50 | > | 250000.0 | nM | - |
| CHEMBL123514 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL121820 | — | EC50 | < | 30.0 | nM | - |
| CHEMBL124246 | — | EC50 | > | 250000.0 | nM | - |
| CHEMBL124248 | — | EC50 | < | 30.0 | nM | - |
| CHEMBL123839 | — | EC50 | > | 250000.0 | nM | - |