Assay Detail
Binding
CHEMBL804269
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Inhibition of HIV-1 reverse transcriptase.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Molecular modeling calculations of HIV-1 reverse transcriptase nonnucleoside inhibitors: correlation of binding energy with biological activity for novel 2-aryl-substituted benzimidazole analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 6.44 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58494 | — | — | 1 | 7.40 |
| CHEMBL57770 | — | — | 1 | 7.35 |
| CHEMBL292831 | — | — | 1 | 7.30 |
| CHEMBL56435 | — | — | 1 | 7.22 |
| CHEMBL58007 | — | — | 1 | 7.22 |
| CHEMBL292923 | — | — | 1 | 7.10 |
| CHEMBL59237 | — | — | 1 | 7.00 |
| CHEMBL294004 | — | — | 1 | 6.80 |
| CHEMBL292138 | — | — | 1 | 6.43 |
| CHEMBL61352 | — | — | 1 | 6.43 |
| CHEMBL291505 | — | — | 1 | 6.40 |
| CHEMBL293961 | — | — | 1 | 6.36 |
| CHEMBL58268 | — | — | 1 | 6.35 |
| CHEMBL293984 | — | — | 1 | 6.28 |
| CHEMBL58607 | — | — | 1 | 6.12 |
| CHEMBL418637 | — | — | 1 | 6.09 |
| CHEMBL59448 | — | — | 1 | 5.87 |
| CHEMBL58358 | — | — | 1 | 5.78 |
| CHEMBL58581 | — | — | 1 | 5.77 |
| CHEMBL294604 | — | — | 1 | 5.62 |
| CHEMBL58797 | — | — | 1 | 5.57 |
| CHEMBL57772 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58494 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL57770 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL292831 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL56435 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL58007 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL292923 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL59237 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL294004 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL292138 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL61352 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL291505 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL293961 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL58268 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL293984 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL58607 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL418637 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL59448 | — | EC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL58358 | — | EC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL58581 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL294604 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL58797 | — | EC50 | = | 2710.0 | nM | 5.57 |
| CHEMBL57772 | — | EC50 | = | 6060.0 | nM | 5.22 |