Assay Detail
Binding
CHEMBL804270
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Inhibitory concentration against HIV-1 reverse transcriptase
91
Total Activities
90
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
A 3D QSAR study of a series of HEPT analogues: the influence of conformational mobility on HIV-1 reverse transcriptase inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 91 | 6.67 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319139 | — | — | 1 | 9.22 |
| CHEMBL310976 | — | — | 1 | 8.80 |
| CHEMBL39015 | — | — | 1 | 8.57 |
| CHEMBL276108 | — | — | 1 | 8.57 |
| CHEMBL97347 | — | — | 1 | 8.57 |
| CHEMBL291926 | — | — | 1 | 8.49 |
| CHEMBL35033 | EMIVIRINE | 2.0 | 1 | 8.38 |
| CHEMBL337338 | — | — | 1 | 8.36 |
| CHEMBL274265 | — | — | 1 | 8.30 |
| CHEMBL288688 | — | — | 1 | 8.23 |
| CHEMBL133035 | — | — | 1 | 8.17 |
| CHEMBL135497 | — | — | 1 | 8.16 |
| CHEMBL336762 | — | — | 1 | 8.13 |
| CHEMBL134403 | — | — | 1 | 8.11 |
| CHEMBL16793 | — | — | 1 | 8.11 |
| CHEMBL38711 | — | — | 1 | 7.92 |
| CHEMBL336388 | — | — | 1 | 7.92 |
| CHEMBL16684 | — | — | 1 | 7.89 |
| CHEMBL340049 | — | — | 1 | 7.89 |
| CHEMBL97745 | — | — | 1 | 7.89 |
| CHEMBL429778 | — | — | 1 | 7.85 |
| CHEMBL133036 | — | — | 1 | 7.85 |
| CHEMBL36995 | — | — | 1 | 7.72 |
| CHEMBL422622 | — | — | 1 | 7.58 |
| CHEMBL54817 | — | — | 1 | 7.41 |
| CHEMBL298821 | — | — | 1 | 7.40 |
| CHEMBL55277 | — | — | 1 | 7.40 |
| CHEMBL81028 | — | — | 1 | 7.39 |
| CHEMBL135367 | 6-Benzyl-5-isopropyl-1-aurus-1H-pyrimidine-2,4-dione | — | 1 | 7.38 |
| CHEMBL17070 | — | — | 1 | 7.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319139 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL310976 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL276108 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL97347 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL39015 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL291926 | — | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL35033 | EMIVIRINE | EC50 | = | 4.2 | nM | 8.38 |
| CHEMBL337338 | — | EC50 | = | 4.4 | nM | 8.36 |
| CHEMBL274265 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL288688 | — | EC50 | = | 5.9 | nM | 8.23 |
| CHEMBL133035 | — | EC50 | = | 6.8 | nM | 8.17 |
| CHEMBL135497 | — | EC50 | = | 6.9 | nM | 8.16 |
| CHEMBL336762 | — | EC50 | = | 7.4 | nM | 8.13 |
| CHEMBL16793 | — | EC50 | = | 7.8 | nM | 8.11 |
| CHEMBL134403 | — | EC50 | = | 7.8 | nM | 8.11 |
| CHEMBL38711 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL336388 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL16684 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL340049 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL97745 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL429778 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL133036 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL36995 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL422622 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL54817 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL298821 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL55277 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL81028 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL135367 | 6-Benzyl-5-isopropyl-1-aurus-1H-pyrimidine-2,4-dione | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL17070 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL328140 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL135589 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL278186 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL275187 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL96032 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL135444 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL417916 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL37067 | — | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL135277 | — | EC50 | = | 91.0 | nM | 7.04 |
| CHEMBL132977 | — | EC50 | = | 96.0 | nM | 7.02 |
| CHEMBL335584 | — | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL39093 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL56036 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL279360 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL279360 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL435961 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL291786 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL134606 | 6-Benzyl-5-ethyl-1-aurus-1H-pyrimidine-2,4-dione | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL135996 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL279409 | — | EC50 | = | 220.0 | nM | 6.66 |