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Assay Detail

CHEMBL804371

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Beta-Lactamase inhibitory activity against represent active class C (P99) serine enzyme
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Beta-lactamase (CHEMBL2026)
Type SINGLE PROTEIN
Organism Escherichia coli K-12

Publication

Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases.
Buynak JD, Chen H, Vogeti L, Gadhachanda VR, Buchanan CA, Palzkill T, Shaw RW, Spencer J, Walsh TR.
Bioorg Med Chem Lett (2004) 14 : 1299 -1304
PubMed 14980686 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.14 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL25644 1 7.00
CHEMBL26275 1 5.85
CHEMBL277225 1 5.43
CHEMBL416561 1 5.41
CHEMBL24235 1 5.12
CHEMBL24275 1 5.10
CHEMBL24878 1 5.00
CHEMBL25766 1 4.98
CHEMBL24351 1 4.37
CHEMBL1439 TAZOBACTAM SODIUM 4.0 1 4.27
CHEMBL277857 1 4.02
CHEMBL25613 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL25644 IC50 = 100.0 nM 7.00
CHEMBL26275 IC50 = 1400.0 nM 5.85
CHEMBL277225 IC50 = 3750.0 nM 5.43
CHEMBL416561 IC50 = 3900.0 nM 5.41
CHEMBL24235 IC50 = 7500.0 nM 5.12
CHEMBL24275 IC50 = 7900.0 nM 5.10
CHEMBL24878 IC50 = 10000.0 nM 5.00
CHEMBL25766 IC50 = 10500.0 nM 4.98
CHEMBL24351 IC50 = 42300.0 nM 4.37
CHEMBL1439 TAZOBACTAM SODIUM IC50 = 53200.0 nM 4.27
CHEMBL277857 IC50 = 96200.0 nM 4.02
CHEMBL25613 IC50 = 409000.0 nM -