Assay Detail
Binding
CHEMBL804437
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In vitro inhibitory concentration against Leishmania major Sterol 24-C-methyltransferase (24-SMT)
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Cycloartenol-C-24-methyltransferase (CHEMBL4264) ↗| Type | SINGLE PROTEIN |
| Organism | Arabidopsis thaliana |
Publication
Azasterols as inhibitors of sterol 24-methyltransferase in Leishmania species and Trypanosoma cruzi.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.45 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2069130 | — | — | 1 | 7.55 |
| CHEMBL3138271 | — | — | 1 | 7.00 |
| CHEMBL3138499 | — | — | 1 | 5.10 |
| CHEMBL2069129 | — | — | 1 | 4.91 |
| CHEMBL3137953 | — | — | 1 | 4.89 |
| CHEMBL3137954 | — | — | 1 | 4.41 |
| CHEMBL3137952 | — | — | 1 | 4.27 |
| CHEMBL3138416 | — | — | 1 | - |
| CHEMBL3138308 | — | — | 1 | - |
| CHEMBL3137957 | — | — | 1 | - |
| CHEMBL3138270 | — | — | 1 | - |
| CHEMBL3138393 | — | — | 1 | - |
| CHEMBL3138314 | — | — | 1 | - |
| CHEMBL3137946 | — | — | 1 | - |
| CHEMBL3138264 | — | — | 1 | - |
| CHEMBL3138302 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2069130 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3138271 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3138499 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL2069129 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL3137953 | — | IC50 | = | 12870.0 | nM | 4.89 |
| CHEMBL3137954 | — | IC50 | = | 38540.0 | nM | 4.41 |
| CHEMBL3137952 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL3138416 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3138308 | — | IC50 | = | - | nM | - |
| CHEMBL3137957 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3138270 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3138393 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3138314 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3137946 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3138264 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3138302 | — | IC50 | > | 100000.0 | nM | - |