Assay Detail
Binding
CHEMBL804516
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Steroid 5-alpha-reductase type I was evaluated as binding affinity of the compound
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (CHEMBL1787) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase by 6-azaandrost-4-en-3-ones: optimization of the C17 substituent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.36 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL420415 | — | — | 1 | 9.05 |
| CHEMBL86418 | — | — | 1 | 7.22 |
| CHEMBL138225 | EPRISTERIDE | 2.0 | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL420415 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL86418 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL138225 | EPRISTERIDE | IC50 | = | 1600.0 | nM | 5.80 |