Assay Detail
Binding
CHEMBL804525
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Apparent IC50 value by [3H]batrachotoxinin-A-20-alpha-benzoate-binding test performed in rat brain synaptosomes
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Synaptosomes |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Anticonvulsant activity and interactions with neuronal voltage-dependent sodium channel of analogues of ameltolide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.84 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283880 | — | — | 1 | 6.96 |
| CHEMBL112463 | — | — | 1 | 6.60 |
| CHEMBL112766 | — | — | 1 | 6.46 |
| CHEMBL16 | PHENYTOIN | 4.0 | 1 | 6.07 |
| CHEMBL22916 | AMELTOLIDE | 2.0 | 1 | 6.01 |
| CHEMBL424612 | — | — | 1 | 5.73 |
| CHEMBL325162 | — | — | 1 | 4.59 |
| CHEMBL432257 | — | — | 1 | 4.32 |
| CHEMBL113918 | — | — | 1 | - |
| CHEMBL8916 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283880 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL112463 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL112766 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL16 | PHENYTOIN | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL22916 | AMELTOLIDE | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL424612 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL325162 | — | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL432257 | — | IC50 | = | 47800.0 | nM | 4.32 |
| CHEMBL113918 | — | IC50 | = | 184000.0 | nM | - |
| CHEMBL8916 | — | IC50 | = | 161000.0 | nM | - |