Assay Detail
Functional
CHEMBL804857
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Inhibition of the growth of Streptococcus faecium
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Enterococcus faecium |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Folate analogues. 31. Synthesis of the reduced derivatives of 11-deazahomofolic acid, 10-methyl-11-deazahomofolic acid, and their evaluation as inhibitors of glycinamide ribonucleotide formyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.40 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 9.05 |
| CHEMBL279302 | — | — | 1 | 7.52 |
| CHEMBL23278 | — | — | 1 | 7.40 |
| CHEMBL284013 | — | — | 1 | 6.92 |
| CHEMBL23699 | — | — | 1 | 6.89 |
| CHEMBL23872 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL279302 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL23278 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL284013 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL23699 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL23872 | — | IC50 | = | 250.0 | nM | 6.60 |