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Assay Detail

CHEMBL804941

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity for Retinoic acid receptor gamma was determined by competing with 3[H]-ATRA
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Retinoic acid receptor gamma (CHEMBL2630)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids.
Michellys PY, Ardecky RJ, Chen JH, D'Arrigo J, Grese TA, Karanewsky DS, Leibowitz MD, Liu S, Mais DA, Mapes CM, Montrose-Rafizadeh C, Ogilvie KM, Reifel-Miller A, Rungta D, Thompson AW, Tyhonas JS, Boehm MF.
J Med Chem (2003) 46 : 4087 -4103
PubMed 12954061 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 17 5.63 5.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL130577 1 5.96
CHEMBL336086 1 5.65
CHEMBL335762 1 5.27
CHEMBL42314 1 -
CHEMBL340555 1 -
CHEMBL129976 1 -
CHEMBL339298 1 -
CHEMBL335751 1 -
CHEMBL132488 1 -
CHEMBL288436 1 -
CHEMBL129887 1 -
CHEMBL133176 1 -
CHEMBL445634 1 -
CHEMBL131561 1 -
CHEMBL130230 1 -
CHEMBL340074 1 -
CHEMBL337719 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL130577 Ki = 1109.0 nM 5.96
CHEMBL336086 Ki = 2221.0 nM 5.65
CHEMBL335762 Ki = 5409.0 nM 5.27
CHEMBL42314 Ki > 1000.0 nM -
CHEMBL340555 Ki > 10000.0 nM -
CHEMBL129976 Ki > 10000.0 nM -
CHEMBL339298 Ki > 10000.0 nM -
CHEMBL335751 Ki > 10000.0 nM -
CHEMBL132488 Ki > 10000.0 nM -
CHEMBL288436 Ki > 1000.0 nM -
CHEMBL129887 Ki > 10000.0 nM -
CHEMBL133176 Ki > 1000.0 nM -
CHEMBL445634 Ki > 10000.0 nM -
CHEMBL131561 Ki > 10000.0 nM -
CHEMBL130230 Ki > 10000.0 nM -
CHEMBL340074 Ki > 10000.0 nM -
CHEMBL337719 Ki > 10000.0 nM -