Assay Detail
Binding
CHEMBL804943
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Transcriptional activation of retinoic acid receptor RAR gamma
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacological activity of conformationally restricted, acetylenic retinoid analogs
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 8.54 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 9.30 |
| CHEMBL275311 | — | — | 1 | 8.62 |
| CHEMBL44478 | — | — | 1 | 8.22 |
| CHEMBL151870 | — | — | 1 | 8.00 |
| CHEMBL150691 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL275311 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL44478 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL151870 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL150691 | — | EC50 | > | 15.0 | nM | - |