Assay Detail
Binding
CHEMBL804950
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Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor gamma using transactivation assay
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of highly potent RXR-specific retinoids: The use of a cyclopropyl group as a double bond isostere
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.73 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 9.15 |
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | 7.35 |
| CHEMBL69091 | — | — | 2 | 6.70 |
| CHEMBL308883 | — | — | 1 | - |
| CHEMBL2111535 | — | — | 1 | - |
| CHEMBL2111534 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL705 | ALITRETINOIN | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL69091 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL308883 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL69091 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL2111535 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL2111534 | — | EC50 | > | 1000.0 | nM | - |