Assay Detail
Functional
CHEMBL804951
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Transcriptional activation of Retinoic acid receptor RAR gamma
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationship studies of novel heteroretinoids: induction of apoptosis in the HL-60 cell line by a novel isoxazole-containing heteroretinoid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 9.30 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 9.30 |
| CHEMBL357015 | — | — | 1 | - |
| CHEMBL92096 | — | — | 1 | - |
| CHEMBL344122 | — | — | 1 | - |
| CHEMBL144058 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL357015 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL92096 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL344122 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL144058 | — | EC50 | > | 1000.0 | nM | - |