Assay Detail
Binding
CHEMBL805014
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity of Sigma opioid receptor type 1 in Guinea pig brain membranes using [3H]pentazocine ligand
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.25 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2112787 | — | — | 1 | 7.01 |
| CHEMBL2112783 | — | — | 1 | 6.98 |
| CHEMBL2112784 | — | — | 1 | 6.86 |
| CHEMBL2112760 | — | — | 1 | 6.26 |
| CHEMBL2112788 | — | — | 1 | 6.22 |
| CHEMBL275707 | RIMCAZOLE | 2.0 | 1 | 6.04 |
| CHEMBL2112789 | — | — | 1 | 5.36 |
| CHEMBL2112791 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2112787 | — | Ki | = | 97.2 | nM | 7.01 |
| CHEMBL2112783 | — | Ki | = | 104.1 | nM | 6.98 |
| CHEMBL2112784 | — | Ki | = | 138.0 | nM | 6.86 |
| CHEMBL2112760 | — | Ki | = | 552.0 | nM | 6.26 |
| CHEMBL2112788 | — | Ki | = | 596.0 | nM | 6.22 |
| CHEMBL275707 | RIMCAZOLE | Ki | = | 908.0 | nM | 6.04 |
| CHEMBL2112789 | — | Ki | = | 4420.0 | nM | 5.36 |
| CHEMBL2112791 | — | Ki | = | 5720.0 | nM | 5.24 |