Assay Detail

CHEMBL805022

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Functional

Inhibitory activity against renin was determined

ChEMBL ↗

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Target

Renin (CHEMBL2322) ↗

Open DB target context

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Primary target Renin

CHEMBL2322

Anchored from Assay target.

Protein identity Renin

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Renin (CHEMBL2322) ↗

Type	SINGLE PROTEIN
Organism	Rattus norvegicus

Publication

Evaluation of the intestinal permeability and hepatic handling of peptidomimetic analogs

Hamilton H, Steinbaugh B, Blankley J, Taylor M, Chan O, Stewart B, Schroeder R, Ryan M, Rapundalo S, Cook J, Bernabei A, Stewart C
Bioorg Med Chem Lett (1993) 3 : 813 -818
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	9.49	9.49

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL34894	—	—	1	9.49

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL34894	—	IC50	=	0.32	nM	9.49