Assay Detail
Binding
CHEMBL805113
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Inhibitory constant of compound against T cell protein tyrosine phosphatase was determined
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | T-cell |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein phosphatase alpha (CHEMBL3918) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.20 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116605 | — | — | 1 | 7.19 |
| CHEMBL333158 | — | — | 1 | 3.20 |
| CHEMBL133541 | ISOXAZOLECARBOXYLIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116605 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL333158 | — | Ki | = | 634000.0 | nM | 3.20 |
| CHEMBL133541 | ISOXAZOLECARBOXYLIC ACID | Ki | = | 202000.0 | nM | - |