Assay Detail
Binding
CHEMBL805131
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Inhibitory activity against Trypanosoma brucei rhodesiense cysteine protease rhodesain
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 4.99 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119370 | — | — | 1 | 6.00 |
| CHEMBL118355 | — | — | 1 | 5.52 |
| CHEMBL333137 | — | — | 1 | 5.46 |
| CHEMBL119213 | — | — | 1 | 5.22 |
| CHEMBL418861 | — | — | 1 | 5.16 |
| CHEMBL119756 | — | — | 1 | 4.82 |
| CHEMBL118210 | — | — | 1 | 4.82 |
| CHEMBL119828 | — | — | 1 | 4.82 |
| CHEMBL119345 | — | — | 1 | 4.82 |
| CHEMBL120254 | — | — | 1 | 4.77 |
| CHEMBL119515 | — | — | 1 | 4.52 |
| CHEMBL118830 | — | — | 1 | 4.00 |
| CHEMBL115581 | — | — | 1 | - |
| CHEMBL118596 | — | — | 1 | - |
| CHEMBL117515 | — | — | 1 | - |
| CHEMBL326294 | ISATIN | — | 1 | - |
| CHEMBL116649 | — | — | 1 | - |
| CHEMBL120076 | — | — | 1 | - |
| CHEMBL117767 | — | — | 1 | - |
| CHEMBL118305 | 5-NITROISATIN | — | 1 | - |
| CHEMBL118638 | — | — | 1 | - |
| CHEMBL336693 | — | — | 1 | - |
| CHEMBL333067 | — | — | 1 | - |
| CHEMBL326185 | — | — | 1 | - |
| CHEMBL324722 | — | — | 1 | - |
| CHEMBL118762 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119370 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL118355 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL333137 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL119213 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL418861 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL119756 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL118210 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL119828 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL119345 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL120254 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL119515 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL118830 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL115581 | — | IC50 | >> | 10000.0 | nM | - |
| CHEMBL118596 | — | IC50 | >> | 10000.0 | nM | - |
| CHEMBL117515 | — | IC50 | >> | 10000.0 | nM | - |
| CHEMBL326294 | ISATIN | IC50 | >> | 10000.0 | nM | - |
| CHEMBL116649 | — | IC50 | >> | 10000.0 | nM | - |
| CHEMBL120076 | — | IC50 | >> | 10000.0 | nM | - |
| CHEMBL117767 | — | IC50 | >> | 10000.0 | nM | - |
| CHEMBL118305 | 5-NITROISATIN | IC50 | >> | 10000.0 | nM | - |
| CHEMBL118638 | — | IC50 | >> | 10000.0 | nM | - |
| CHEMBL336693 | — | IC50 | >> | 10000.0 | nM | - |
| CHEMBL333067 | — | IC50 | >> | 10000.0 | nM | - |
| CHEMBL326185 | — | IC50 | >> | 10000.0 | nM | - |
| CHEMBL324722 | — | IC50 | >> | 10000.0 | nM | - |
| CHEMBL118762 | — | IC50 | >> | 10000.0 | nM | - |