Assay Detail
Binding
CHEMBL805228
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Binding affinity against sigma-2 receptor in rat liver using radioligand [3H]DTG in the presence of dextrallorphan.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Expert |
Publication
Synthesis and characterization of [125I]-N-(N-benzylpiperidin-4-yl)-4- iodobenzamide, a new sigma receptor radiopharmaceutical: high-affinity binding to MCF-7 breast tumor cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.40 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50112 | — | — | 1 | 7.60 |
| CHEMBL46326 | — | — | 1 | 7.53 |
| CHEMBL539938 | — | — | 1 | 7.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50112 | — | Ki | = | 25.2 | nM | 7.60 |
| CHEMBL46326 | — | Ki | = | 29.6 | nM | 7.53 |
| CHEMBL539938 | — | Ki | = | 84.6 | nM | 7.07 |