Assay Detail
Functional
CHEMBL805254
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In vitro antitumor activity against SW480 (colon) human tumor cell lines.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW480 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and antitumor activity of bicyclic and isomeric analogues of illudin M
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.72 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8640 | — | — | 1 | 7.52 |
| CHEMBL8350 | — | — | 1 | 7.52 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.22 |
| CHEMBL8312 | — | — | 1 | 7.22 |
| CHEMBL8039 | — | — | 1 | 6.75 |
| CHEMBL195491 | DEHYDROILLUDIN M | — | 1 | 6.52 |
| CHEMBL8744 | — | — | 1 | 5.60 |
| CHEMBL7993 | — | — | 1 | 5.40 |
| CHEMBL274328 | — | — | 1 | - |
| CHEMBL7994 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8640 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL8350 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL8312 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL8039 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL195491 | DEHYDROILLUDIN M | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL8744 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL7993 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL274328 | — | IC50 | 120.0 | nM | - | |
| CHEMBL7994 | — | IC50 | > | 10000.0 | nM | - |