Assay Detail
Functional
CHEMBL805260
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The compound was tested for inhibition of HIV-1 replication in SW480 cells using HIV tat assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | SW480 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Protein Tat (CHEMBL4609) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus type 1 group M subtype B (isolate PCV12)(HIV-1) |
Publication
Keto/enol epoxy steroids as HIV-1 Tat inhibitors: structure-activity relationships and pharmacophore localization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 4.96 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3137917 | — | — | 1 | 5.58 |
| CHEMBL3137919 | — | — | 1 | 5.58 |
| CHEMBL3137916 | — | — | 1 | 5.57 |
| CHEMBL109492 | — | — | 1 | 5.55 |
| CHEMBL3137910 | — | — | 1 | 5.44 |
| CHEMBL91609 | — | — | 1 | 5.40 |
| CHEMBL323490 | — | — | 1 | 5.35 |
| CHEMBL320506 | — | — | 1 | 5.16 |
| CHEMBL2373330 | — | — | 1 | 5.08 |
| CHEMBL3137920 | — | — | 1 | 5.08 |
| CHEMBL108427 | — | — | 1 | 5.00 |
| CHEMBL3137913 | — | — | 1 | 4.99 |
| CHEMBL3137911 | — | — | 1 | 4.84 |
| CHEMBL3137914 | — | — | 1 | 4.81 |
| CHEMBL107878 | — | — | 1 | 4.78 |
| CHEMBL108485 | — | — | 1 | 4.67 |
| CHEMBL3138234 | — | — | 1 | 4.61 |
| CHEMBL111446 | — | — | 1 | 4.59 |
| CHEMBL111424 | — | — | 1 | 4.50 |
| CHEMBL323217 | — | — | 1 | 4.49 |
| CHEMBL325765 | — | — | 1 | 4.47 |
| CHEMBL110573 | — | — | 1 | 4.47 |
| CHEMBL320265 | — | — | 1 | 4.14 |
| CHEMBL326009 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3137917 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3137919 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3137916 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL109492 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3137910 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL91609 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL323490 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL320506 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2373330 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL3137920 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL108427 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL3137913 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL3137911 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL3137914 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL107878 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL108485 | — | IC50 | = | 21400.0 | nM | 4.67 |
| CHEMBL3138234 | — | IC50 | = | 24500.0 | nM | 4.61 |
| CHEMBL111446 | — | IC50 | = | 25700.0 | nM | 4.59 |
| CHEMBL111424 | — | IC50 | = | 31700.0 | nM | 4.50 |
| CHEMBL323217 | — | IC50 | = | 32100.0 | nM | 4.49 |
| CHEMBL325765 | — | IC50 | = | 33500.0 | nM | 4.47 |
| CHEMBL110573 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL320265 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL326009 | — | IC50 | = | 278000.0 | nM | - |