Assay Detail
Binding
CHEMBL805368
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Inhibition of Src protein tyrosine kinase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCbeta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.55 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 9.00 |
| CHEMBL54382 | — | — | 1 | 4.96 |
| CHEMBL55394 | — | — | 1 | 4.17 |
| CHEMBL52654 | — | — | 1 | 4.08 |
| CHEMBL432130 | — | — | 1 | - |
| CHEMBL300138 | ENZASTAURIN | 3.0 | 1 | - |
| CHEMBL300549 | — | — | 1 | - |
| CHEMBL53596 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL54382 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL55394 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL52654 | — | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL432130 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL300138 | ENZASTAURIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL300549 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL53596 | — | IC50 | > | 100000.0 | nM | - |