Assay Detail
Functional
CHEMBL805639
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration needed to inhibit 50% growth of human SKBr3 (breast carcinoma) cell lines
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-BR-3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile inhibitors of epidermal growth factor receptor kinase and their bioisosteric relationship to the 4-anilino-6,7-dialkoxyquinazoline inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 51 | 5.71 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL111443 | — | — | 1 | 7.22 |
| CHEMBL109212 | — | — | 1 | 7.05 |
| CHEMBL111442 | — | — | 1 | 6.57 |
| CHEMBL1203037 | — | — | 1 | 6.44 |
| CHEMBL112225 | — | — | 1 | 6.41 |
| CHEMBL109372 | — | — | 1 | 6.33 |
| CHEMBL111038 | — | — | 1 | 6.32 |
| CHEMBL324045 | — | — | 1 | 6.31 |
| CHEMBL1203088 | — | — | 1 | 6.28 |
| CHEMBL111664 | — | — | 1 | 6.27 |
| CHEMBL111307 | — | — | 1 | 6.26 |
| CHEMBL109515 | — | — | 1 | 6.25 |
| CHEMBL109476 | — | — | 1 | 6.19 |
| CHEMBL110065 | — | — | 1 | 6.19 |
| CHEMBL432396 | — | — | 1 | 6.13 |
| CHEMBL109575 | — | — | 1 | 6.10 |
| CHEMBL29197 | — | — | 1 | 6.09 |
| CHEMBL109355 | — | — | 1 | 6.03 |
| CHEMBL110577 | — | — | 1 | 6.02 |
| CHEMBL113535 | — | — | 1 | 5.94 |
| CHEMBL326445 | — | — | 1 | 5.92 |
| CHEMBL110945 | — | — | 1 | 5.89 |
| CHEMBL110055 | — | — | 1 | 5.86 |
| CHEMBL323900 | — | — | 1 | 5.83 |
| CHEMBL324399 | — | — | 1 | 5.81 |
| CHEMBL1203026 | — | — | 1 | 5.81 |
| CHEMBL1203059 | — | — | 1 | 5.77 |
| CHEMBL109428 | — | — | 1 | 5.75 |
| CHEMBL110062 | — | — | 1 | 5.71 |
| CHEMBL111520 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL111443 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL109212 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL111442 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1203037 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL112225 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL109372 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL111038 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL324045 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL1203088 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL111664 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL111307 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL109515 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL110065 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL109476 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL432396 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL109575 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL29197 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL109355 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL110577 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL113535 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL326445 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL110945 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL110055 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL323900 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL1203026 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL324399 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL1203059 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL109428 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL110062 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL111520 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL419185 | — | IC50 | = | 2017.0 | nM | 5.70 |
| CHEMBL110036 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL111586 | — | IC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL323424 | — | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL109332 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL325760 | — | IC50 | = | 5120.0 | nM | 5.29 |
| CHEMBL325981 | — | IC50 | = | 5070.0 | nM | 5.29 |
| CHEMBL443277 | — | IC50 | = | 6210.0 | nM | 5.21 |
| CHEMBL109625 | — | IC50 | = | 6740.0 | nM | 5.17 |
| CHEMBL114446 | — | IC50 | = | 7780.0 | nM | 5.11 |
| CHEMBL320479 | — | IC50 | = | 8290.0 | nM | 5.08 |
| CHEMBL323970 | — | IC50 | = | 8440.0 | nM | 5.07 |
| CHEMBL83228 | — | IC50 | = | 13160.0 | nM | 4.88 |
| CHEMBL109503 | — | IC50 | = | 13420.0 | nM | 4.87 |
| CHEMBL111222 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL439596 | — | IC50 | = | 15360.0 | nM | 4.81 |
| CHEMBL112096 | — | IC50 | = | 16120.0 | nM | 4.79 |
| CHEMBL1203047 | — | IC50 | = | 24960.0 | nM | 4.60 |
| CHEMBL111033 | — | IC50 | = | 25970.0 | nM | 4.59 |
| CHEMBL109259 | — | IC50 | = | 27670.0 | nM | 4.56 |