Assay Detail
Binding
CHEMBL805748
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Inhibition of [3H]-DTG binding to sigma-2 receptor of rat liver membranes with 1 uM dextrallorphan
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Expert |
Publication
Substituted halogenated arylsulfonamides: a new class of sigma receptor binding tumor imaging agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.55 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL83430 | — | — | 1 | 7.89 |
| CHEMBL81455 | — | — | 1 | 7.63 |
| CHEMBL309983 | — | — | 1 | 7.35 |
| CHEMBL439765 | — | — | 1 | 6.72 |
| CHEMBL79660 | — | — | 1 | 6.70 |
| CHEMBL81500 | — | — | 1 | 6.69 |
| CHEMBL83448 | — | — | 1 | 6.47 |
| CHEMBL82081 | — | — | 1 | 6.35 |
| CHEMBL79841 | — | — | 1 | 6.34 |
| CHEMBL79840 | — | — | 1 | 6.00 |
| CHEMBL81360 | — | — | 1 | 5.83 |
| CHEMBL81451 | — | — | 1 | 5.62 |
| CHEMBL81389 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL83430 | — | Ki | = | 12.8 | nM | 7.89 |
| CHEMBL81455 | — | Ki | = | 23.5 | nM | 7.63 |
| CHEMBL309983 | — | Ki | = | 44.4 | nM | 7.35 |
| CHEMBL439765 | — | Ki | = | 189.0 | nM | 6.72 |
| CHEMBL79660 | — | Ki | = | 198.0 | nM | 6.70 |
| CHEMBL81500 | — | Ki | = | 206.0 | nM | 6.69 |
| CHEMBL83448 | — | Ki | = | 337.0 | nM | 6.47 |
| CHEMBL82081 | — | Ki | = | 449.0 | nM | 6.35 |
| CHEMBL79841 | — | Ki | = | 459.0 | nM | 6.34 |
| CHEMBL79840 | — | Ki | = | 1002.0 | nM | 6.00 |
| CHEMBL81360 | — | Ki | = | 1487.0 | nM | 5.83 |
| CHEMBL81451 | — | Ki | = | 2393.0 | nM | 5.62 |
| CHEMBL81389 | — | Ki | = | 2826.0 | nM | 5.55 |