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Assay Detail

CHEMBL805867

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Concentration needed to inhibit 50% growth of human SW620 (colon carcinoma) cell lines
ChEMBL ↗
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SW-620
Confidence 1 — Organism
Curated By Expert

Target

SW-620 (CHEMBL612262) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile inhibitors of epidermal growth factor receptor kinase and their bioisosteric relationship to the 4-anilino-6,7-dialkoxyquinazoline inhibitors.
Wissner A, Berger DM, Boschelli DH, Floyd MB, Greenberger LM, Gruber BC, Johnson BD, Mamuya N, Nilakantan R, Reich MF, Shen R, Tsou HR, Upeslacis E, Wang YF, Wu B, Ye F, Zhang N.
J Med Chem (2000) 43 : 3244 -3256
PubMed 10966743 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 51 5.22 7.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL111443 — — 1 7.22
CHEMBL109212 — — 1 6.80
CHEMBL111442 — — 1 6.37
CHEMBL324045 — — 1 6.31
CHEMBL1203037 — — 1 6.00
CHEMBL109372 — — 1 5.64
CHEMBL324399 — — 1 5.56
CHEMBL110945 — — 1 5.56
CHEMBL111307 — — 1 5.54
CHEMBL325981 — — 1 5.54
CHEMBL432396 — — 1 5.54
CHEMBL326445 — — 1 5.52
CHEMBL110055 — — 1 5.51
CHEMBL323424 — — 1 5.46
CHEMBL419185 — — 1 5.46
CHEMBL111038 — — 1 5.43
CHEMBL109625 — — 1 5.42
CHEMBL323900 — — 1 5.42
CHEMBL110062 — — 1 5.38
CHEMBL109515 — — 1 5.37
CHEMBL110065 — — 1 5.37
CHEMBL111586 — — 1 5.34
CHEMBL113535 — — 1 5.32
CHEMBL112096 — — 1 5.30
CHEMBL1203026 — — 1 5.30
CHEMBL109332 — — 1 5.28
CHEMBL111664 — — 1 5.27
CHEMBL323970 — — 1 5.20
CHEMBL325760 — — 1 5.20
CHEMBL443277 — — 1 5.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL111443 — IC50 = 60.0 nM 7.22
CHEMBL109212 — IC50 = 160.0 nM 6.80
CHEMBL111442 — IC50 = 430.0 nM 6.37
CHEMBL324045 — IC50 = 490.0 nM 6.31
CHEMBL1203037 — IC50 = 990.0 nM 6.00
CHEMBL109372 — IC50 = 2300.0 nM 5.64
CHEMBL324399 — IC50 = 2740.0 nM 5.56
CHEMBL110945 — IC50 = 2750.0 nM 5.56
CHEMBL111307 — IC50 = 2890.0 nM 5.54
CHEMBL325981 — IC50 = 2900.0 nM 5.54
CHEMBL432396 — IC50 = 2870.0 nM 5.54
CHEMBL326445 — IC50 = 3010.0 nM 5.52
CHEMBL110055 — IC50 = 3090.0 nM 5.51
CHEMBL419185 — IC50 = 3430.0 nM 5.46
CHEMBL323424 — IC50 = 3510.0 nM 5.46
CHEMBL111038 — IC50 = 3720.0 nM 5.43
CHEMBL109625 — IC50 = 3800.0 nM 5.42
CHEMBL323900 — IC50 = 3760.0 nM 5.42
CHEMBL110062 — IC50 = 4180.0 nM 5.38
CHEMBL109515 — IC50 = 4320.0 nM 5.37
CHEMBL110065 — IC50 = 4240.0 nM 5.37
CHEMBL111586 — IC50 = 4520.0 nM 5.34
CHEMBL113535 — IC50 = 4740.0 nM 5.32
CHEMBL112096 — IC50 = 4980.0 nM 5.30
CHEMBL1203026 — IC50 = 4980.0 nM 5.30
CHEMBL109332 — IC50 = 5240.0 nM 5.28
CHEMBL111664 — IC50 = 5340.0 nM 5.27
CHEMBL323970 — IC50 = 6290.0 nM 5.20
CHEMBL325760 — IC50 = 6300.0 nM 5.20
CHEMBL443277 — IC50 = 6930.0 nM 5.16
CHEMBL109428 — IC50 = 7060.0 nM 5.15
CHEMBL110577 — IC50 = 7800.0 nM 5.11
CHEMBL83228 — IC50 = 8760.0 nM 5.06
CHEMBL114446 — IC50 = 9870.0 nM 5.01
CHEMBL111222 — IC50 = 9790.0 nM 5.01
CHEMBL112225 — IC50 = 11830.0 nM 4.93
CHEMBL320479 — IC50 = 13520.0 nM 4.87
CHEMBL29197 — IC50 = 13940.0 nM 4.86
CHEMBL110036 — IC50 = 14330.0 nM 4.84
CHEMBL109575 — IC50 = 17020.0 nM 4.77
CHEMBL111520 — IC50 = 17270.0 nM 4.76
CHEMBL1203059 — IC50 = 19170.0 nM 4.72
CHEMBL439596 — IC50 = 23150.0 nM 4.63
CHEMBL109355 — IC50 = 24960.0 nM 4.60
CHEMBL1203088 — IC50 = 29530.0 nM 4.53
CHEMBL109503 — IC50 = 35630.0 nM 4.45
CHEMBL111033 — IC50 = 43290.0 nM 4.36
CHEMBL1203047 — IC50 = 48490.0 nM 4.31
CHEMBL541988 — IC50 = 53820.0 nM 4.27
CHEMBL109476 — IC50 = 60430.0 nM 4.22