Assay Detail
Binding
CHEMBL805895
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Src protein tyrosine kinase
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of Src kinase activity by 4-anilino-5,10-dihydro-pyrimido[4,5-b]quinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.62 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 8.92 |
| CHEMBL100551 | — | — | 1 | 8.64 |
| CHEMBL102000 | — | — | 1 | 8.48 |
| CHEMBL101917 | — | — | 1 | 8.37 |
| CHEMBL100172 | — | — | 1 | 8.01 |
| CHEMBL322689 | — | — | 1 | 7.80 |
| CHEMBL100651 | — | — | 1 | 7.52 |
| CHEMBL414013 | — | — | 1 | 6.30 |
| CHEMBL7137 | — | — | 1 | 4.50 |
| CHEMBL450015 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288441 | BOSUTINIB | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL100551 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL102000 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL101917 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL100172 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL322689 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL100651 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL414013 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL7137 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL450015 | — | IC50 | > | 10000.0 | nM | - |