Assay Detail
Binding
CHEMBL805972
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human TNF-alpha converting enzyme
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Disintegrin and metalloproteinase domain-containing protein 17 (CHEMBL3706) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological activity of selective azasugar-based TACE inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 9.01 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43087 | — | — | 1 | 9.28 |
| CHEMBL288664 | — | — | 1 | 9.24 |
| CHEMBL41821 | — | — | 1 | 9.08 |
| CHEMBL288843 | — | — | 1 | 8.73 |
| CHEMBL291264 | — | — | 1 | 8.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43087 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL288664 | — | Ki | = | 0.57 | nM | 9.24 |
| CHEMBL41821 | — | Ki | = | 0.84 | nM | 9.08 |
| CHEMBL288843 | — | Ki | = | 1.85 | nM | 8.73 |
| CHEMBL291264 | — | Ki | = | 1.85 | nM | 8.73 |