Assay Detail
Binding
CHEMBL806010
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Inhibition of [3H]9-cis-RA binding to Retinoid X receptor RXR beta
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of novel retinoic acid receptor agonists having potent antiproliferative activity in cervical cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.11 | 8.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | 8.13 |
| CHEMBL89241 | — | — | 2 | 7.99 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL705 | ALITRETINOIN | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL89241 | — | Ki | = | 10.2 | nM | 7.99 |
| CHEMBL89241 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL38 | TRETINOIN | Ki | = | 881.0 | nM | 6.05 |